Synthetic embryology

RESEARCH

 

LAB NEWS

 

  • 1/13/2021. Congrats to Manolo for passing his qualifying exam!

  • 1/1/2021. Happy New Year! Welcome Weronika and Matt, our newest grad students!

  • 12/1/2020. Check out our latest review on the material properties of centrosomes.

  • 9/8/2020. The lab welcomes Malgosia, our newest member!

  • 6/15/2020. Jeff was selected as one of 22 nationwide Pew Scholars in the Biomedical Sciences.

  • 6/8/2020. We welcome Nicole and Jessica to the lab.

FEATURED MOVIE

We use light to induce flows within a living embryo. This allows us to apply tunable force against centrosomes to study their material properties. In the movie, FLUCS deforms and ruptures a centrosome (green) during anaphase. DNA is magenta.

Mittasch, Tran et al., 2020 Journal of Cell Biology

As we age, we become less fertile and prone to cancer. These two problems involve defective quality control during cell division. How do normal cells divide and prevent problems? And what happens as our cells age? We use synthetic biology, live-cell imaging, and nano-scale rheology to understand how oocytes and stem cells guard themselves against ageing and faulty cell division.